Pancreatic Elastase ELISA
Intended use:
For In-vitro diagnostic use. Enzyme linked immunosorbent assay (ELISA) for the quantitative determination of human pancreatic elastase in feces as an aid in the diagnosis of the exocrine pancreatic function.
General Information:
Pancreatic Elastase is a proteolytic enzyme exclusively produced in pancreas. It is stable during the intestinal passage and is even accumulated in a sixfold concentration in stool, compared to the concentration in the duodenal juice. The widely utilized ELISA for the quantitative determination of pancreatic elastase in feces enables to obtain a quick and reliable diagnosis and follow-up of an exocrine pancreatic insufficiency, which may be caused by:
- Chronic pancreatitis
- Cystic fibrosis
- Diabetes mellitus
- Cholelithiasis
- Hereditary Pancreatitis
- Chronical- inflammatory bowel disease
- Pancreatic carcinoma
- Autoimmunologically caused pancreatitis
- Shwachman-Diamond-Syndrome
- Zollinger-Ellison-Syndrome
Pankrin® ELISA
Intended use:
For In-vitro diagnostic use. Enzyme linked immunosorbent assay (ELISA) for the quantitative determination of pancreatic elastase and other pancreatic enzymes for the diagnosis of acute pancreatitis in human serum.
General Information:
An acute pancreatitis, the acute inflammation of the pancreas, is mostly caused by the dystopic protease activation in the azinus cells, the obstruction of the luminal secretion and the formation of intracellular vacuoles (Schneider 1999). The yearly incidence rate is 50 to 100 cases per 100.000 persons. The clinical picture is determined by pronounced abdominal pain and general symptoms like nausea, vomiting and circulatory collapse (Selberg et al. 1995). The mild form of an acute pancreatitis, the endematous pancreatitis (ca. 80% of all cases of an acute pancreatitis) progresses without complications and under adequate therapy patients normally recover within 72 hours. The severe form of an acute pancreatitis, the hemorrhagic narcotising pancreatitis is characterized by necrosis and by a protracted course with frequent failure of organs or organ systems (Asanuma at. al. 1999, Singer et al. 1988). Morphologically a thickening and irregular delimitation of the pancreas can be observed as well as an accumulation of liquid in the peritoneal space. The main cause of an acute pancreatitis are an increased alcohol consumption (Blank et al. 1999, Lankisch 2000) and trapped gallstones which possibly get into the pancreatic duct via a reflux (Niederau et al. 1997, UHL et al. 1999, Sharma et al. 1999).
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